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Amino Acids

氨基酸

Amino acids are organic compounds which contain both an amino group and a carboxyl group.

氨基酸是含有氨基和羧基的有机化合物。

Amino acids have the general form:

氨基酸具有通用结构:
R-group
R基团
Hydrocarbon
碳氢化合物
Neutral
中性
Acid or base
酸或碱

Here the COOH is understood to be the carboxyl group shown above. There are 20 amino acids which make up the proteins of living organisms, distinguished by the R-groups. The simplest of the amino acids, glycine, has just H as an R-group. The list of these 20 amino acids at right may be clicked for further information. The single-letter representations of these amino acids are included.

此处的COOH被理解为上图所示的羧基集团。构成生物体蛋白质的20种氨基酸因R基团不同而有所区别。最简单的氨基酸——甘氨酸,其R基团仅为H。右侧的20种氨基酸列表可点击以获取更多信息。这些氨基酸的单字母表示也已包含在内。

Amino acids are the structural elements from which proteins are built. When amino acids bond to each other, it is done in the form of an amide , making a connection which is called a peptide linkage. This can be illustrated with the two simplest amino acids, glycine and alanine.

氨基酸是构成蛋白质的结构单元。当氨基酸相互结合时,它们通过酰胺形式连接,这种连接称为肽键。这可以通过最简单的两种氨基酸——甘氨酸和丙氨酸来示例。

"Amino acids are used to synthesize certain hormones, other amino acids, some neurotransmitters (chemicals used in communication between neurons), and new proteins. These proteins have diverse roles in the body, acting as enzymes, receptors on cell membranes, oxygen transport molecules (hemoglobin), structural components (hair and nails), hormones, antibodies, and muscle proteins."(Audesirks)

氨基酸被用来合成某些激素,其他氨基酸,一些神经递质(神经元间通信所用的化学物质),以及新的蛋白质。这些蛋白质在体内具有多样的功能,充当酶、细胞膜上的受体、氧运输分子(血红蛋白)、结构成分(头发和指甲)、激素、抗体和肌肉蛋白质。

Active graphic
活动图形

According to Tillery, et al., the human body can synthesize all of the amino acids necessary to build proteins except for the ten called the "essential amino acids", indicated by asterisks in the amino acid illustrations. An adequate diet must contain these essential amino acids. Typically, they are supplied by meat and dairy products, but if those are not consumed, some care must be applied to ensuring an adequate supply. They can be supplied by a combination of cereal grains (wheat, corn, rice, etc.) and legumes (beans,peanuts, etc.). Tillery points out that a number of popular ethnic foods involve such a combination, so that in a single dish, one might hope to get the ten essential amino acids. Mexican corn and beans, Japanese rice and soybeans, and Cajun red beans and rice are examples of such fortuitous combinations.

根据Tillery等人所述,人体可以合成构建蛋白质所需的全部氨基酸,除了被称为“必需氨基酸”的十种,这些在氨基酸示意图中用星号标出。一个充足的饮食必须包含这些必需氨基酸。通常,它们通过肉类和乳制品提供,但如果这些食物未被摄入,就必须注意确保足够的供应。它们也可以通过谷物(如小麦、玉米、大米等)和豆类(如豆子、花生等)的组合来提供。Tillery指出,许多流行的民族食物都包含这样的组合,因此在一道菜肴中,人们或许可以期望获得十种必需氨基酸。墨西哥的玉米和豆类、日本的大米和大豆、路易斯安那州的红豆和米饭都是这种幸运组合的例子。

Amino acids can form in either left-handed or right-handed molecular symmetry, but it is notable that all life on the Earth contains left-handed amino acids as the building blocks of its proteins. This fact makes remarkable the amino acids found in the Murchison meteorite, which were nearly equal mixtures of left- and right-handed amino acids for the central portion. That equal population itself would have been convincing evidence of its extra-terrestrial origin even if it had not been observed to impact near Murchison, Australia in 1969. There is some element of mystery why the Murchison meteorite did show some elevation of L-amino acid after contamination was accounted for, as did meteorite GRA 95229 from Antarctica.

氨基酸可以以左旋或右旋分子对称性形成,但值得注意的是,地球上的所有生命都以左旋氨基酸作为蛋白质的构建块。这一事实使在Murchison陨石中发现的氨基酸显得尤为突出,这些氨基酸几乎等量地混合了左旋和右旋氨基酸。这种平衡的分布本身即使在没有观察到1969年该陨石撞击澳大利亚Murchison之前,也足以证明其外星起源。为什么Murchison陨石在去除污染后仍显示出左旋氨基酸的偏高,以及南极的陨石GRA 95229也表现出类似现象,仍存在一些神秘之处。

Wiki: amino acid

氨基酸
Index

Biochemical concepts

Chemistry concepts

References
Shipman, Wilson and Todd
Ch 15

Tillery, Enger and Ross
Ch 14

Audesirk & Audesirk
Ch 29

Matthews, van Holde, Ahern
Ch 5
索引 生物化学概念 化学概念 参考文献 Shipman, Wilson and Todd 第15章 Tillery, Enger and Ross 第14章 Audesirk & Audesirk 第29章 Matthews, van Holde, Ahern 第5章
 
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Peptide Bonds

肽键

The joining of amino acids in the process of making biochemical molecules like proteins is done by bonds which are referred to as peptide bonds. This may be illustrated with the two simplest amino acids, glycine and alanine.

在合成生物分子如蛋白质的过程中,氨基酸通过称为肽键的化学键连接在一起。这种连接可以用最简单的两种氨基酸——甘氨酸和丙氨酸来说明。
Index

Biochemical concepts

Chemistry concepts

Reference
Shipman, Wilson and Todd
Ch 15
索引 生物化学概念 化学概念 参考 Shipman, Wilson and Todd 第15章
 
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